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Basics
| Name | Jonah O'Mara Schwartz |
| Title | Ph.D. Student - Integrated Program in Biochemistry |
| Summary | Ph.D. student and protein engineer with extensive experience in synthetic biology, biochemical engineering, high-throughput protein screening, and molecular cloning. |
Work
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2020.10 - 2023.07 Protein Engineer 2
Ginkgo Bioworks
Led R&D program developing a biosensor and ultra-high-throughput in-vivo screen to improve protein biophysical characteristics.
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2019.07 - 2020.10 Research Associate 1
Broad Institute: Genetic Perturbation Platform
Created and evaluated large pooled DNA libraries for CRISPR, RNAi, ORF screening.
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2018.06 - 2018.08 Process Biochemistry Intern
Biogen
Developed rapid purification schemes for Aducanumab and explored alternative purification technologies.
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2016.09 - 2019.01 Undergraduate Researcher
Tufts University, Wolfe Lab
Studied the farm biome and cabbage phyllosphere to discover sources of lactobacillus.
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2016.06 - 2016.08 -
2014.06 - 2014.08 Chromatography Research Intern
Repligen
Developed improved column packing procedures for agarose and cellulose chromatography resins.
Education
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2023.09 - Present -
2015.09 - 2019.05 -
2011.09 - 2015.06
Awards
- 2023.09.01
T32 NIH Biotechnology Training Grant
National Institutes of Health
Publications
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2025.06.07 Computation-guided redesign of promoter specificity of a bacterial {RNA} polymerase
Bioarxiv Preprint
Engineering sigma 70 towards new promoter sequences
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2020.06.01 A Gnotobiotic System for Studying Microbiome Assembly in the Phyllosphere and in Vegetable Fermentation
Journal of Visualized Experiments (JoVE)
Describes methods for creating a gnotobiotic system to study microbiome assembly.
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2019.06.01 Establishment Limitation Constrains the Abundance of Lactic Acid Bacteria in the Napa Cabbage Phyllosphere
Applied and Environmental Microbiology
Discusses constraints on lactic acid bacteria establishment in the cabbage phyllosphere.
Skills
| Protein Engineering & Biochemistry | |
| NGS Analysis | |
| FACS / Flow Cytometry | |
| Protein Design | |
| Protein Purification |
| Molecular Biology Techniques | |
| Molecular Cloning | |
| Golden Gate Cloning | |
| Gibson Assembly | |
| Variant Library Construction | |
| PCR | |
| SDS-PAGE | |
| Western Blot | |
| Chromatography |
| Software & Programming | |
| Python | |
| Bash | |
| AWS (Infrastructure) | |
| Pymol | |
| Rosetta Design | |
| Schrodinger Maestro | |
| FlowJo | |
| SnapGene | |
| Geneious |